At the US Open, she made it to the third round, defeating her doubles partner Radwańska before losing to Li Na.
She then competed in the Korea Open in Seoul, where she was the defending champion, but lost in the semifinals to eventual champion Kimiko Date-Krumm.
Her next opponent was Daniela Hantuchová, to whom she lost, 6–1, 4–6, 4–6, after leading 6–1, 3–1.
Kirilenko then reached the second round of a Tier-I event in Doha, beating Ekaterina Makarova, before losing to Anabel Medina Garrigues in three sets.
She also won the doubles title there, partnering with Flavia Pennetta.
Kirilenko also won in Barcelona, defeating Martinez-Sanchez for her fourth career WTA title and the second of the year.
She reached three Grand Slam singles quarterfinals, at the 2010 Australian Open, the 2012 Wimbledon Championships, and the 2013 French Open.
In women's doubles, she reached two Grand Slam finals, at the 2011 Australian Open and the 2012 French Open, won the 2012 WTA Tour Championships and was a bronze medalist at the 2012 London Olympics.
Kirilenko was seeded 27th at the Australian Open, but lost to future top five player Sara Errani in the first round.In the World Group quarterfinal tie against Belgium, she lost her singles match against 2005 US Open champion Kim Clijsters, but partnering with Dinara Safina, won her doubles match against Justine Henin and Clijsters. In January 2007, she advanced to the third round of the Australian Open, before being defeated by third seed Svetlana Kuznetsova.She then competed in the Toray Pan Pacific Open in Tokyo, where she advanced to the second round, upsetting world No.In the Dubai doubles tournament, Kirilenko partnered with Agnieszka Radwańska, and even though they were unseeded, they reached the final, eventually losing to Liezel Huber and Cara Black, the world No. At the 2009 French Open, Kirilenko was unseeded in the singles tournament, and lost to Olivia Rogowska of Australia in the first round.In the doubles tournament, Kirilenko and doubles partner Flavia Pennetta of Italy were seeded eighth.